![]() Adding, they consume less of a 1% sucrose solution than controls in a preference test that was performed during two hours with animals deprived of food and water for 18 hours, and that had received previous training of 48 hours of exposure to water and a 1% sucrose solution (Baghya et al., 2008).ĬLI rats have shortens the onset latency of REM sleep and increases REM sleep periods (Frank & Heller, 1997 Mirmiran, van de Poll, Corner, de Boer & van Oyen, 1980 Mirmiran, van de Poll, Corner, van Oyen & Bour 1981 Mirmiran et al., 1983 Vogel, Neill, Kors & Hagler, 1990) and produces permanent alteration of plasma corticosterone levels (e.g., Prathiba, Kumar & Karanth, 1998). Newborn rats treated with CLI show a decrease in their weight (e.g., de Boer, Mirmiran, van Haaren, Louwerse & van de Poll, 1989 Hansen & Mikkelsen, 1998 Maciag et al., 2006 Mirmiran et al., 1983), decreases pleasure-seeking behavior (Vogel, Neill, Hagler & Kors, 1990b), they were significantly less aggressive (e.g., Martinez-Gonzalez, Prospero-Garcia, Mihailescu & Drucker-Colin, 2002) and they increase immobility in a forced swim test, one of the most widely used procedures for the assessment of depressive behaviors (Baghya, Srikumar, Taju & Shankaranarayana Rao, 2008 Bonilla-Jaime, Retana-Marquez, Vazquez-Palacios & VelazquezMoctezuma, 2003 Porsolt, Le Pichon & Jalfre, 1977 Vazquez-Palacios, Bonilla-Jaime & Velazquez-Moctezuma, 2005). However, newborn animals treated with CLI exhibit behavioral and neurobiological abnormalities resembling endogenous depression in adult life (e.g., Vogel & Vogel, 1982 Vogel, Neill, Hagler & Kors, 1990a). CLI rats showed a faster recovery from the cSNC than control animals, which may be explained by an alteration of the Hypothalamic-Pituitary-Adrenal axis (HPA), a serotonergic system deficit, a low expectative formation during pre-shift phase, or a combination of all these factors.Īdministration of clomipramine (CLI), a serotonin and norepinephrine reuptake inhibitor, is commonly used for depression treatment. ![]() The findings of the present work suggest that the neonatal treatment with an antidepressive could generate an increase tolerance to frustration in adult animals. We studied whether neonatal treatment with CLI alters the cSNC's response in adult rats. It triggers an aversive-emotional reaction similar to fear or anxiety. In consummatory successive negative contrast (cSNC), rats that have had experience drinking 32% sucrose solution drink significantly less 4% sucrose solution than rats that have drunk only 4% solution. Neonatal administration of clomipramine (CLI) produces physiological, neuroendocrinal and behavioral abnormalities in rats when they reach adulthood, which are similar to those observed in animal models of depression. Este resultado puede explicarse por una alteracion del eje Hipotalamo-Pituitario-Adrenal (HPA), por un deterioro del sistema serotoninergico, por la formacion de una baja expectativa durante la fase de pre-cambio, o por una combinacion de estos factores. Los animales a los que se les administro neonatalmente CLI presentaron una recuperacion mas rapida en el CSNc, que los animales controles sin tratamiento neonatal. ![]() Los hallazgos del presente trabajo sugieren que el tratamiento neonatal con un antidepresivo podria generar un aumento en la tolerancia a la frustracion en animales adultos. En el presente trabajo, estudiamos si el tratamiento neonatal con CLI altera la respuesta de CSNc en ratas adultas. Este modelo de devaluacion del incentivo produce en los animales una reaccion emocional similar al miedo y la ansiedad. En el Contraste Sucesivo Negativo consumatorio (CSNc), las ratas que recibieron una solucion de sacarosa al 32%, consumen menos de una solucion de sacarosa al 4%, que los animales que siempre recibieron la solucion 4%. La administracion neonatal de clomipramina (CLI) produce alteraciones fisiologicas, neuroendocrinas y comportamentales en las ratas adultas, que son similares a las observadas en los modelos animales de depresion. Efecto del tratamiento neonatal con clomipramina sobre el Contraste Sucesivo Negativo consumatorio.
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